DBF4 [The Human Chemical-Genetic Interaction Map Project]

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======= DBF4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DBF4
  * **<color #00a2e8>Official Name</color>**: DBF4 zinc finger
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10926|10926]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBU7|Q9UBU7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DBF4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DBF4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604281|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-DBF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Dbf4-dependent protein kinase complex|
|positive regulation of nuclear cell cycle DNA replication|
|positive regulation of DNA-dependent DNA replication|
|regulation of nuclear cell cycle DNA replication|
|protein serine/threonine kinase activator activity|
|positive regulation of DNA replication|
|enzyme activator activity|
|regulation of DNA-dependent DNA replication|
|regulation of DNA replication|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|nucleic acid binding|
|DNA replication|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|nuclear body|
|positive regulation of cell cycle process|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of cell cycle|
|regulation of cell cycle phase transition|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|mitotic cell cycle process|
|positive regulation of transferase activity|
|mitotic cell cycle|
|regulation of cell cycle process|
|regulation of protein kinase activity|
|zinc ion binding|
|regulation of kinase activity|
|regulation of transferase activity|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of cell cycle|
|positive regulation of protein modification process|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.9|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.85|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.76|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.72|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.78|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.82|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.93|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.02|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.04|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.18|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 133/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|6/28|
|bone|6/26|
|breast|5/33|
|central nervous system|6/56|
|cervix|1/4|
|colorectal|10/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|5/21|
|liver|2/20|
|lung|12/75|
|lymphocyte|1/16|
|ovary|4/26|
|pancreas|6/24|
|peripheral nervous system|3/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10034
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DBF4 Expression in NALM6 Cells: 6.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>