DBF4

Entrez Summary: N/A
UniProt Summary: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 133/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	8/28
blood	6/28
bone	6/26
breast	5/33
central nervous system	6/56
cervix	1/4
colorectal	10/17
esophagus	4/13
fibroblast	0/1
gastric	1/16
kidney	5/21
liver	2/20
lung	12/75
lymphocyte	1/16
ovary	4/26
pancreas	6/24
peripheral nervous system	3/16
plasma cell	3/15
prostate	0/1
skin	3/24
soft tissue	2/9
thyroid	1/2
upper aerodigestive	4/22
urinary tract	5/29
uterus	1/5

Expression Distribution

Dbf4-dependent protein kinase complex
positive regulation of nuclear cell cycle DNA replication
positive regulation of DNA-dependent DNA replication
regulation of nuclear cell cycle DNA replication
protein serine/threonine kinase activator activity
positive regulation of DNA replication
enzyme activator activity
regulation of DNA-dependent DNA replication
regulation of DNA replication
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
nucleic acid binding
DNA replication
mitotic cell cycle phase transition
cell cycle phase transition
nuclear body
positive regulation of cell cycle process
positive regulation of protein serine/threonine kinase activity
positive regulation of cell cycle
regulation of cell cycle phase transition
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of kinase activity
mitotic cell cycle process
positive regulation of transferase activity
mitotic cell cycle
regulation of cell cycle process
regulation of protein kinase activity
zinc ion binding
regulation of kinase activity
regulation of transferase activity
cell cycle process
positive regulation of protein phosphorylation
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
regulation of cell cycle
positive regulation of protein modification process
cell cycle
positive regulation of catalytic activity