DCHS1 [The Human Chemical-Genetic Interaction Map Project]

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======= DCHS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCHS1
  * **<color #00a2e8>Official Name</color>**: dachsous cadherin-related 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8642|8642]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96JQ0|Q96JQ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCHS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCHS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603057|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302). {ECO:0000269|PubMed:26258302}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|condensed mesenchymal cell proliferation|
|mitral valve formation|
|cell migration involved in endocardial cushion formation|
|atrioventricular valve formation|
|mitral valve morphogenesis|
|mitral valve development|
|heart valve formation|
|ossification involved in bone maturation|
|cell migration involved in heart development|
|mesenchymal cell proliferation|
|bone maturation|
|post-anal tail morphogenesis|
|endocardial cushion formation|
|animal organ maturation|
|atrioventricular valve morphogenesis|
|atrioventricular valve development|
|hippo signaling|
|endocardial cushion morphogenesis|
|endocardial cushion development|
|branching involved in ureteric bud morphogenesis|
|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|mesenchyme morphogenesis|
|cochlea development|
|heart valve morphogenesis|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|heart valve development|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|apical part of cell|
|nephron tubule development|
|renal tubule development|
|kidney morphogenesis|
|ureteric bud development|
|mesonephric tubule development|
|mesonephric epithelium development|
|mesonephros development|
|nephron epithelium development|
|nephron development|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|digestive tract development|
|anatomical structure maturation|
|digestive system development|
|morphogenesis of a branching epithelium|
|neural tube development|
|morphogenesis of a branching structure|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|protein localization to plasma membrane|
|inner ear development|
|bone development|
|mesenchyme development|
|ear development|
|protein localization to cell periphery|
|developmental maturation|
|heart morphogenesis|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|ossification|
|kidney development|
|renal system development|
|epithelial tube morphogenesis|
|urogenital system development|
|morphogenesis of an epithelium|
|pattern specification process|
|protein localization to membrane|
|skeletal system development|
|cell-cell adhesion|
|heart development|
|sensory organ development|
|cell population proliferation|
|tissue morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|calcium ion binding|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|embryo development|
|localization of cell|
|cell motility|
|epithelium development|
|locomotion|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|intracellular signal transduction|
|tissue development|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11302
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCHS1 Expression in NALM6 Cells: -0.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>