DCHS1

Entrez Summary: This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008].
UniProt Summary: Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302). {ECO:0000269|PubMed:26258302}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

condensed mesenchymal cell proliferation
mitral valve formation
cell migration involved in endocardial cushion formation
atrioventricular valve formation
mitral valve morphogenesis
mitral valve development
heart valve formation
ossification involved in bone maturation
cell migration involved in heart development
mesenchymal cell proliferation
bone maturation
post-anal tail morphogenesis
endocardial cushion formation
animal organ maturation
atrioventricular valve morphogenesis
atrioventricular valve development
hippo signaling
endocardial cushion morphogenesis
endocardial cushion development
branching involved in ureteric bud morphogenesis
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
mesenchyme morphogenesis
cochlea development
heart valve morphogenesis
ureteric bud morphogenesis
mesonephric tubule morphogenesis
heart valve development
nephron tubule morphogenesis
nephron epithelium morphogenesis
nephron morphogenesis
renal tubule morphogenesis
apical part of cell
nephron tubule development
renal tubule development
kidney morphogenesis
ureteric bud development
mesonephric tubule development
mesonephric epithelium development
mesonephros development