DCP1A [The Human Chemical-Genetic Interaction Map Project]

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======= DCP1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCP1A
  * **<color #00a2e8>Official Name</color>**: decapping mRNA 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55802|55802]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPI6|Q9NPI6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCP1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCP1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607010|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DCP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|deadenylation-independent decapping of nuclear-transcribed mRNA|
|nuclear-transcribed mRNA catabolic process, deadenylation-independent decay|
|protein localization to cytoplasmic stress granule|
|deadenylation-dependent decapping of nuclear-transcribed mRNA|
|exonucleolytic catabolism of deadenylated mRNA|
|nuclear-transcribed mRNA catabolic process, exonucleolytic|
|kinesin binding|
|enzyme activator activity|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|cytoplasmic ribonucleoprotein granule|
|hydrolase activity|
|P-body|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|regulation of mRNA stability|
|regulation of RNA stability|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|regulation of mRNA metabolic process|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|mRNA metabolic process|
|protein localization to organelle|
|regulation of cellular catabolic process|
|cellular macromolecule catabolic process|
|regulation of catabolic process|
|macromolecule catabolic process|
|identical protein binding|
|positive regulation of catalytic activity|
|cellular protein localization|
|cellular macromolecule localization|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.32|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.01|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.84|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.84|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.84|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.77|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.74|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.71|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.7|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18108
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCP1A Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>