DCP1A

Gene Information

Official Symbol: DCP1A
Official Name: decapping mRNA 1A
Aliases and Previous Symbols: N/A
Entrez ID: 55802
UniProt: Q9NPI6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
QNZ 0.01μM R08 exp439	-2.32
UM0131023 0.05μM R05 exp248	-2.01
EPZ-5676 30μM R05 exp233	-1.84
LB-100 2μM R05 exp210	-1.84
NFN1 0.4μM R03 exp99	-1.84
CB-839 10μM R05 exp224	-1.77
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.74
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.71
ETC-159 50μM R08 exp480	-1.7
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.87

Essentiality in NALM6

Essentiality Rank: 18108
Expression level (log2 read counts): 6.11

Expression Distribution

deadenylation-independent decapping of nuclear-transcribed mRNA
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
protein localization to cytoplasmic stress granule
deadenylation-dependent decapping of nuclear-transcribed mRNA
exonucleolytic catabolism of deadenylated mRNA
nuclear-transcribed mRNA catabolic process, exonucleolytic
kinesin binding
enzyme activator activity
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
cytoplasmic ribonucleoprotein granule
hydrolase activity
P-body
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
regulation of mRNA stability
regulation of RNA stability
nuclear-transcribed mRNA catabolic process
regulation of mRNA catabolic process
mRNA catabolic process
RNA catabolic process
nucleic acid phosphodiester bond hydrolysis
regulation of mRNA metabolic process
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
posttranscriptional regulation of gene expression
mRNA metabolic process
protein localization to organelle
regulation of cellular catabolic process
cellular macromolecule catabolic process
regulation of catabolic process
macromolecule catabolic process
identical protein binding
positive regulation of catalytic activity
cellular protein localization
cellular macromolecule localization
RNA metabolic process
negative regulation of gene expression
organic substance catabolic process