DCT

Entrez Summary: N/A
UniProt Summary: Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:8306979). Involved in regulating eumelanin and phaeomelanin levels. {ECO:0000269|PubMed:8306979}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

melanin biosynthetic process from tyrosine
ventricular zone neuroblast division
dopachrome isomerase activity
forebrain ventricular zone progenitor cell division
forebrain neuroblast division
tyrosine metabolic process
melanin biosynthetic process
melanin metabolic process
melanosome membrane
neuroblast division
neuronal stem cell division
secondary metabolite biosynthetic process
positive regulation of neuroblast proliferation
somatic stem cell division
cell proliferation in forebrain
neuroblast proliferation
regulation of neuroblast proliferation
stem cell division
phenol-containing compound biosynthetic process
positive regulation of stem cell proliferation
aromatic amino acid family metabolic process
developmental pigmentation
pigment biosynthetic process
positive regulation of neural precursor cell proliferation
stem cell proliferation
secondary metabolic process
copper ion binding
pigment metabolic process
regulation of stem cell proliferation
forebrain generation of neurons
neural precursor cell proliferation
phenol-containing compound metabolic process
regulation of neural precursor cell proliferation
pigmentation
melanosome
oxidoreductase activity
organic hydroxy compound biosynthetic process
alpha-amino acid metabolic process
cellular amino acid metabolic process
forebrain development