DCTPP1 [The Human Chemical-Genetic Interaction Map Project]

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======= DCTPP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCTPP1
  * **<color #00a2e8>Official Name</color>**: dCTP pyrophosphatase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79077|79077]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H773|Q9H773]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCTPP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCTPP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615840|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. {ECO:0000269|PubMed:24467396}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MazG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dTTP catabolic process|
|dCTP catabolic process|
|pyrimidine deoxyribonucleotide binding|
|dCTP diphosphatase activity|
|dCTP metabolic process|
|pyrimidine nucleoside triphosphate catabolic process|
|pyrimidine deoxyribonucleoside triphosphate catabolic process|
|DNA protection|
|dTTP metabolic process|
|pyrimidine deoxyribonucleoside triphosphate metabolic process|
|nucleoside-triphosphate diphosphatase activity|
|deoxyribonucleoside triphosphate catabolic process|
|pyrimidine deoxyribonucleotide catabolic process|
|nucleoside triphosphate catabolic process|
|pyrimidine nucleotide catabolic process|
|deoxyribonucleoside triphosphate metabolic process|
|deoxyribonucleotide catabolic process|
|pyrimidine deoxyribonucleotide metabolic process|
|deoxyribose phosphate catabolic process|
|pyrimidine nucleoside triphosphate metabolic process|
|2-deoxyribonucleotide metabolic process|
|deoxyribose phosphate metabolic process|
|deoxyribonucleotide metabolic process|
|pyrimidine-containing compound catabolic process|
|pyrimidine nucleotide metabolic process|
|nucleotide catabolic process|
|nucleoside phosphate catabolic process|
|protein homotetramerization|
|nucleoside triphosphate metabolic process|
|pyrimidine-containing compound metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|organophosphate catabolic process|
|protein tetramerization|
|carbohydrate derivative catabolic process|
|magnesium ion binding|
|cellular response to extracellular stimulus|
|cellular response to external stimulus|
|protein homooligomerization|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|protein complex oligomerization|
|response to extracellular stimulus|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|DNA metabolic process|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-2.21|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12565
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCTPP1 Expression in NALM6 Cells: 5.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>