DCTPP1

Gene Information

Official Symbol: DCTPP1
Official Name: dCTP pyrophosphatase 1
Aliases and Previous Symbols: N/A
Entrez ID: 79077
UniProt: Q9H773
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. {ECO:0000269|PubMed:24467396}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12565
Expression level (log2 read counts): 5.67

Expression Distribution

Screen	Score
Zebularine 20μM R07 exp423	-2.21
Ethambutol 25μM R08 exp481	1.92

dTTP catabolic process
dCTP catabolic process
pyrimidine deoxyribonucleotide binding
dCTP diphosphatase activity
dCTP metabolic process
pyrimidine nucleoside triphosphate catabolic process
pyrimidine deoxyribonucleoside triphosphate catabolic process
DNA protection
dTTP metabolic process
pyrimidine deoxyribonucleoside triphosphate metabolic process
nucleoside-triphosphate diphosphatase activity
deoxyribonucleoside triphosphate catabolic process
pyrimidine deoxyribonucleotide catabolic process
nucleoside triphosphate catabolic process
pyrimidine nucleotide catabolic process
deoxyribonucleoside triphosphate metabolic process
deoxyribonucleotide catabolic process
pyrimidine deoxyribonucleotide metabolic process
deoxyribose phosphate catabolic process
pyrimidine nucleoside triphosphate metabolic process
2-deoxyribonucleotide metabolic process
deoxyribose phosphate metabolic process
deoxyribonucleotide metabolic process
pyrimidine-containing compound catabolic process
pyrimidine nucleotide metabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
protein homotetramerization
nucleoside triphosphate metabolic process
pyrimidine-containing compound metabolic process
nucleobase-containing small molecule biosynthetic process
organophosphate catabolic process
protein tetramerization
carbohydrate derivative catabolic process
magnesium ion binding
cellular response to extracellular stimulus
cellular response to external stimulus
protein homooligomerization
nucleobase-containing compound catabolic process
heterocycle catabolic process