DCUN1D2

Entrez Summary: N/A
UniProt Summary: Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8- conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. {ECO:0000269|PubMed:23201271}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Fas-L 44ng/ml R08 exp482	-1.93
Trientine 500μM R08 exp534	-1.91
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.87
Arsenate 40μM R06 exp264	-1.81
Golgicide-A 2μM R03 exp121	-1.8

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ubiquitin-like protein binding
protein neddylation
cullin family protein binding
ubiquitin conjugating enzyme binding
positive regulation of ubiquitin-protein transferase activity
regulation of ubiquitin-protein transferase activity
ubiquitin ligase complex
positive regulation of protein ubiquitination
positive regulation of protein modification by small protein conjugation or removal
regulation of protein ubiquitination
regulation of protein modification by small protein conjugation or removal
positive regulation of transferase activity
protein modification by small protein conjugation
regulation of transferase activity
protein modification by small protein conjugation or removal
positive regulation of protein modification process
positive regulation of catalytic activity
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
positive regulation of molecular function
regulation of protein modification process