DCUN1D3

Gene Information

Official Symbol: DCUN1D3
Official Name: defective in cullin neddylation 1 domain containing 3
Aliases and Previous Symbols: N/A
Entrez ID: 123879
UniProt: Q8IWE4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211). {ECO:0000269|PubMed:25349211}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10735
Expression level (log2 read counts): 3.8

Expression Distribution

ubiquitin-like protein binding
protein neddylation
response to UV-C
cullin family protein binding
positive regulation of ubiquitin-protein transferase activity
ubiquitin conjugating enzyme binding
regulation of ubiquitin-protein transferase activity
response to gamma radiation
negative regulation of G1/S transition of mitotic cell cycle
ubiquitin ligase complex
negative regulation of cell cycle G1/S phase transition
positive regulation of protein ubiquitination
positive regulation of protein modification by small protein conjugation or removal
response to UV
response to ionizing radiation
regulation of G1/S transition of mitotic cell cycle
regulation of cell cycle G1/S phase transition
negative regulation of cell growth
regulation of protein ubiquitination
negative regulation of mitotic cell cycle phase transition
regulation of protein modification by small protein conjugation or removal
negative regulation of cell cycle phase transition
negative regulation of growth
response to light stimulus
negative regulation of mitotic cell cycle
negative regulation of cell cycle process
post-translational protein modification
regulation of mitotic cell cycle phase transition
regulation of cell growth
response to radiation
regulation of cell cycle phase transition
negative regulation of cell cycle
regulation of mitotic cell cycle
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of transferase activity
regulation of growth
positive regulation of cell death
perinuclear region of cytoplasm
regulation of cell cycle process