DCXR

Entrez Summary: The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010].
UniProt Summary: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

KR
adh short

L-xylulose reductase (NAD+) activity
L-xylulose reductase (NADP+) activity
D-xylose metabolic process
xylulose metabolic process
glucuronate catabolic process
xylulose 5-phosphate metabolic process
carbonyl reductase (NADPH) activity
glucuronate catabolic process to xylulose 5-phosphate
xylulose 5-phosphate biosynthetic process
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
pentose metabolic process
uronic acid metabolic process
glucuronate metabolic process
NADP metabolic process
brush border
cytoplasmic microtubule
monosaccharide catabolic process
microvillus
protein homotetramerization
glucose metabolic process
monocarboxylic acid catabolic process
carbohydrate catabolic process
protein tetramerization
hexose metabolic process
monosaccharide metabolic process
carboxylic acid catabolic process
organic acid catabolic process
protein homooligomerization
small molecule catabolic process
carbohydrate metabolic process
protein complex oligomerization
monocarboxylic acid metabolic process
organophosphate biosynthetic process
carbohydrate derivative biosynthetic process
organophosphate metabolic process
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process