DDAH1

Gene Information

Official Symbol: DDAH1
Official Name: dimethylarginine dimethylaminohydrolase 1
Aliases and Previous Symbols: N/A
Entrez ID: 23576
UniProt: O94760
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8088
Expression level (log2 read counts): -4.01

Expression Distribution

Screen	Score
Metformin 40μM R03 exp132	1.78
Cannabidiol 13μM R08 exp465	1.8

dimethylargininase activity
negative regulation of cellular response to hypoxia
citrulline metabolic process
arginine catabolic process
negative regulation of vascular permeability
regulation of cellular response to hypoxia
arginine metabolic process
amino acid binding
nitric oxide mediated signal transduction
glutamine family amino acid catabolic process
regulation of vascular permeability
positive regulation of nitric oxide biosynthetic process
positive regulation of nitric oxide metabolic process
regulation of nitric-oxide synthase activity
catalytic activity
positive regulation of reactive oxygen species biosynthetic process
regulation of monooxygenase activity
regulation of nitric oxide biosynthetic process
glutamine family amino acid metabolic process
regulation of reactive oxygen species biosynthetic process
regulation of systemic arterial blood pressure
positive regulation of reactive oxygen species metabolic process
regulation of oxidoreductase activity
alpha-amino acid catabolic process
cellular amino acid catabolic process
positive regulation of angiogenesis
vascular process in circulatory system
regulation of reactive oxygen species metabolic process
regulation of blood pressure
positive regulation of vasculature development
alpha-amino acid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
regulation of angiogenesis
cellular amino acid metabolic process
regulation of vasculature development
second-messenger-mediated signaling
regulation of neurotransmitter levels
blood circulation
circulatory system process