DDAH2

Gene Information

Official Symbol: DDAH2
Official Name: dimethylarginine dimethylaminohydrolase 2
Aliases and Previous Symbols: N/A
Entrez ID: 23564
UniProt: O95865
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. {ECO:0000269|PubMed:10493931}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9093
Expression level (log2 read counts): 4.33

Expression Distribution

dimethylargininase activity
citrulline metabolic process
arginine catabolic process
nitric oxide biosynthetic process
nitric oxide metabolic process
arginine metabolic process
amino acid binding
nitric oxide mediated signal transduction
reactive nitrogen species metabolic process
reactive oxygen species biosynthetic process
glutamine family amino acid catabolic process
positive regulation of nitric oxide biosynthetic process
positive regulation of nitric oxide metabolic process
neurotransmitter biosynthetic process
regulation of nitric-oxide synthase activity
catalytic activity
positive regulation of reactive oxygen species biosynthetic process
regulation of monooxygenase activity
regulation of nitric oxide biosynthetic process
glutamine family amino acid metabolic process
regulation of reactive oxygen species biosynthetic process
neurotransmitter metabolic process
regulation of oxidoreductase activity
positive regulation of reactive oxygen species metabolic process
alpha-amino acid catabolic process
reactive oxygen species metabolic process
cellular amino acid catabolic process
microtubule organizing center
regulation of reactive oxygen species metabolic process
alpha-amino acid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
cellular amino acid metabolic process
second-messenger-mediated signaling
regulation of neurotransmitter levels
small molecule catabolic process
drug metabolic process
negative regulation of apoptotic process
negative regulation of programmed cell death
carboxylic acid metabolic process