DDX24 [The Human Chemical-Genetic Interaction Map Project]

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======= DDX24 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDX24
  * **<color #00a2e8>Official Name</color>**: DEAD-box helicase 24
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57062|57062]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZR7|Q9GZR7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDX24&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDX24|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606181|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  ATP-dependent RNA helicase. {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Helicase C|
|DEAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA helicase activity|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|ATP binding|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-2.01|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.85|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.75|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 448/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|13/28|
|blood|19/28|
|bone|15/26|
|breast|18/33|
|central nervous system|30/56|
|cervix|3/4|
|colorectal|13/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|6/16|
|kidney|21/21|
|liver|10/20|
|lung|41/75|
|lymphocyte|8/16|
|ovary|14/26|
|pancreas|17/24|
|peripheral nervous system|13/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|12/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|11/22|
|urinary tract|13/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2213
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDX24 Expression in NALM6 Cells: 8.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>