DDX24

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pyronaridine 1μM R06 exp295	-2.01
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.85
Parthenolide 2.5μM R05 exp238	1.75
UM0131023 0.05μM R05 exp248	2

Global Fraction of Cell Lines Where Essential: 448/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	13/28
blood	19/28
bone	15/26
breast	18/33
central nervous system	30/56
cervix	3/4
colorectal	13/17
esophagus	8/13
fibroblast	1/1
gastric	6/16
kidney	21/21
liver	10/20
lung	41/75
lymphocyte	8/16
ovary	14/26
pancreas	17/24
peripheral nervous system	13/16
plasma cell	12/15
prostate	1/1
skin	12/24
soft tissue	7/9
thyroid	1/2
upper aerodigestive	11/22
urinary tract	13/29
uterus	2/5

Expression Distribution

Helicase C
DEAD

RNA helicase activity
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA binding
ATP binding
RNA metabolic process
membrane
gene expression