DDX39B [The Human Chemical-Genetic Interaction Map Project]

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======= DDX39B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDX39B
  * **<color #00a2e8>Official Name</color>**: DExD-box helicase 39B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7919|7919]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13838|Q13838]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDX39B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDX39B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142560|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEAD|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA-dependent ATPase activity|
|negative regulation of DNA damage checkpoint|
|negative regulation of cell cycle checkpoint|
|U4 snRNA binding|
|RNA secondary structure unwinding|
|viral mRNA export from host cell nucleus|
|U6 snRNP|
|ATP-dependent protein binding|
|positive regulation of cell growth involved in cardiac muscle cell development|
|translocation of molecules into host|
|translocation of molecules into other organism involved in symbiotic interaction|
|U6 snRNA binding|
|U4 snRNP|
|transcription export complex|
|regulation of DNA damage checkpoint|
|regulation of cell growth involved in cardiac muscle cell development|
|positive regulation of cardiac muscle cell differentiation|
|positive regulation of cardiocyte differentiation|
|positive regulation of cardiac muscle hypertrophy|
|positive regulation of DNA-templated transcription, elongation|
|positive regulation of muscle hypertrophy|
|regulation of cell cycle checkpoint|
|positive regulation of cardiac muscle tissue growth|
|positive regulation of vascular smooth muscle cell proliferation|
|regulation of cardiac muscle cell differentiation|
|positive regulation of heart growth|
|positive regulation of cardiac muscle tissue development|
|positive regulation of organ growth|
|regulation of vascular smooth muscle cell proliferation|
|regulation of DNA-templated transcription, elongation|
|regulation of cardiocyte differentiation|
|spliceosomal complex assembly|
|regulation of cardiac muscle hypertrophy|
|regulation of cardiac muscle tissue growth|
|positive regulation of striated muscle cell differentiation|
|regulation of muscle hypertrophy|
|regulation of heart growth|
|RNA helicase activity|
|positive regulation of DNA biosynthetic process|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|multi-organism transport|
|multi-organism localization|
|positive regulation of muscle tissue development|
|regulation of cardiac muscle tissue development|
|negative regulation of response to DNA damage stimulus|
|mRNA 3-end processing|
|regulation of muscle adaptation|
|positive regulation of smooth muscle cell proliferation|
|positive regulation of muscle cell differentiation|
|spliceosomal complex|
|regulation of organ growth|
|regulation of striated muscle cell differentiation|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|nuclear matrix|
|regulation of DNA biosynthetic process|
|ribonucleoprotein complex export from nucleus|
|liver development|
|positive regulation of translation|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|hepaticobiliary system development|
|regulation of striated muscle tissue development|
|regulation of smooth muscle cell proliferation|
|regulation of muscle tissue development|
|RNA 3-end processing|
|regulation of muscle organ development|
|protein export from nucleus|
|positive regulation of cellular amide metabolic process|
|regulation of muscle cell differentiation|
|mRNA transport|
|interaction with host|
|nuclear export|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|RNA transport|
|nucleic acid transport|
|positive regulation of DNA metabolic process|
|establishment of RNA localization|
|RNA localization|
|regulation of response to DNA damage stimulus|
|ribonucleoprotein complex assembly|
|regulation of muscle system process|
|ATPase activity|
|nucleobase-containing compound transport|
|ribonucleoprotein complex subunit organization|
|protein-containing complex localization|
|positive regulation of growth|
|nucleocytoplasmic transport|
|nuclear transport|
|protein-containing complex binding|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|regulation of developmental growth|
|regulation of translation|
|regulation of DNA metabolic process|
|positive regulation of cell cycle|
|RNA splicing|
|nuclear speck|
|regulation of cellular amide metabolic process|
|gland development|
|regulation of cell growth|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|posttranscriptional regulation of gene expression|
|positive regulation of cell development|
|regulation of system process|
|regulation of growth|
|mRNA metabolic process|
|regulation of cellular response to stress|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|RNA processing|
|positive regulation of cell population proliferation|
|regulation of cell development|
|positive regulation of cell differentiation|
|intracellular protein transport|
|identical protein binding|
|regulation of cell cycle|
|positive regulation of developmental process|
|RNA binding|
|regulation of response to stress|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.2|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.14|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.05|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.8|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.71|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.7|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.72|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.72|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.72|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.78|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.78|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.8|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.8|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.86|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.88|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.91|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.96|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.05|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.05|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.16|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.19|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 17/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|2/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|0/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1487
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDX39B Expression in NALM6 Cells: 9.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>