DDX39B
Gene Information
- Official Symbol: DDX39B
- Official Name: DExD-box helicase 39B
- Aliases and Previous Symbols: N/A
- Entrez ID: 7919
- UniProt: Q13838
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| DEAD |
| Helicase C |
GO Terms
| RNA-dependent ATPase activity |
| negative regulation of DNA damage checkpoint |
| negative regulation of cell cycle checkpoint |
| U4 snRNA binding |
| RNA secondary structure unwinding |
| viral mRNA export from host cell nucleus |
| U6 snRNP |
| ATP-dependent protein binding |
| positive regulation of cell growth involved in cardiac muscle cell development |
| translocation of molecules into host |
| translocation of molecules into other organism involved in symbiotic interaction |
| U6 snRNA binding |
| U4 snRNP |
| transcription export complex |
| regulation of DNA damage checkpoint |
| regulation of cell growth involved in cardiac muscle cell development |
| positive regulation of cardiac muscle cell differentiation |
| positive regulation of cardiocyte differentiation |
| positive regulation of cardiac muscle hypertrophy |
| positive regulation of DNA-templated transcription, elongation |
| positive regulation of muscle hypertrophy |
| regulation of cell cycle checkpoint |
| positive regulation of cardiac muscle tissue growth |
| positive regulation of vascular smooth muscle cell proliferation |
| regulation of cardiac muscle cell differentiation |
| positive regulation of heart growth |
| positive regulation of cardiac muscle tissue development |
| positive regulation of organ growth |
| regulation of vascular smooth muscle cell proliferation |
| regulation of DNA-templated transcription, elongation |
| regulation of cardiocyte differentiation |
| spliceosomal complex assembly |
| regulation of cardiac muscle hypertrophy |
| regulation of cardiac muscle tissue growth |
| positive regulation of striated muscle cell differentiation |
| regulation of muscle hypertrophy |
| regulation of heart growth |
| RNA helicase activity |
| positive regulation of DNA biosynthetic process |
| positive regulation of striated muscle tissue development |
| positive regulation of muscle organ development |
| multi-organism transport |
| multi-organism localization |
| positive regulation of muscle tissue development |
| regulation of cardiac muscle tissue development |
| negative regulation of response to DNA damage stimulus |
| mRNA 3-end processing |
| regulation of muscle adaptation |
| positive regulation of smooth muscle cell proliferation |
| positive regulation of muscle cell differentiation |
| spliceosomal complex |
| regulation of organ growth |
| regulation of striated muscle cell differentiation |
| mRNA export from nucleus |
| mRNA-containing ribonucleoprotein complex export from nucleus |
| nuclear matrix |
| regulation of DNA biosynthetic process |
| ribonucleoprotein complex export from nucleus |
| liver development |
| positive regulation of translation |
| ribonucleoprotein complex localization |
| RNA export from nucleus |
| hepaticobiliary system development |
| regulation of striated muscle tissue development |
| regulation of smooth muscle cell proliferation |
| regulation of muscle tissue development |
| RNA 3-end processing |
| regulation of muscle organ development |
| protein export from nucleus |
| positive regulation of cellular amide metabolic process |
| regulation of muscle cell differentiation |
| mRNA transport |
| interaction with host |
| nuclear export |
| positive regulation of cell growth |
| positive regulation of developmental growth |
| RNA transport |
| nucleic acid transport |
| positive regulation of DNA metabolic process |
| establishment of RNA localization |
| RNA localization |
| regulation of response to DNA damage stimulus |
| ribonucleoprotein complex assembly |
| regulation of muscle system process |
| ATPase activity |
| nucleobase-containing compound transport |
| ribonucleoprotein complex subunit organization |
| protein-containing complex localization |
| positive regulation of growth |
| nucleocytoplasmic transport |
| nuclear transport |
| protein-containing complex binding |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions |
| regulation of developmental growth |
| regulation of translation |
| regulation of DNA metabolic process |
| positive regulation of cell cycle |
| RNA splicing |
| nuclear speck |
| regulation of cellular amide metabolic process |
| gland development |
| regulation of cell growth |
| ribonucleoprotein complex biogenesis |
| mRNA processing |
| posttranscriptional regulation of gene expression |
| positive regulation of cell development |
| regulation of system process |
| regulation of growth |
| mRNA metabolic process |
| regulation of cellular response to stress |
| symbiotic process |
| interspecies interaction between organisms |
| cellular protein-containing complex assembly |
| RNA processing |
| positive regulation of cell population proliferation |
| regulation of cell development |
| positive regulation of cell differentiation |
| intracellular protein transport |
| identical protein binding |
| regulation of cell cycle |
| positive regulation of developmental process |
| RNA binding |
| regulation of response to stress |
| ATP binding |
| protein transport |
| intracellular transport |
| peptide transport |
| positive regulation of transcription, DNA-templated |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 17/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 2/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 2/16 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 1/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1487
- Expression level (log2 read counts): 9.32
Expression Distribution
DDX39B Expression in NALM6 Cells: 9.32
