DDX47 [The Human Chemical-Genetic Interaction Map Project]

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======= DDX47 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDX47
  * **<color #00a2e8>Official Name</color>**: DEAD-box helicase 47
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51202|51202]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H0S4|Q9H0S4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDX47&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDX47|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615428|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors. {ECO:0000269|PubMed:15977068, ECO:0000269|PubMed:16963496}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEAD|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extrinsic apoptotic signaling pathway via death domain receptors|
|RNA helicase activity|
|extrinsic apoptotic signaling pathway|
|rRNA processing|
|rRNA metabolic process|
|apoptotic signaling pathway|
|ribosome biogenesis|
|ncRNA processing|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|mRNA processing|
|mRNA metabolic process|
|nucleolus|
|RNA processing|
|apoptotic process|
|programmed cell death|
|cell death|
|RNA binding|
|ATP binding|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.95|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-2.22|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.21|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.2|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.7|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.74|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.82|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.85|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|1.87|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.89|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.94|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|2.02|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.02|
|[[:results:exp285|GW501516 25μM R06 exp285]]|2.13|
|[[:results:exp187|proTAME 5μM R04 exp187]]|2.21|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.23|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.493|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.47|
|[[:human genes:p:prim1|PRIM1]]|0.468|
|[[:human genes:t:tfip11|TFIP11]]|0.457|
|[[:human genes:c:chd4|CHD4]]|0.457|
|[[:human genes:t:tyms|TYMS]]|0.451|
|[[:human genes:r:rpl6|RPL6]]|0.449|
|[[:human genes:t:tceb3c|TCEB3C]]|0.447|
|[[:human genes:c:cdh24|CDH24]]|0.439|
|[[:human genes:s:slc4a1|SLC4A1]]|0.438|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.437|
|[[:human genes:c:cope|COPE]]|0.435|
|[[:human genes:w:wdr75|WDR75]]|0.433|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.431|
|[[:human genes:c:c14orf93|C14orf93]]|0.429|
|[[:human genes:c:cbwd3|CBWD3]]|0.429|
|[[:human genes:e:exosc9|EXOSC9]]|0.425|
|[[:human genes:p:psmb2|PSMB2]]|0.422|
|[[:human genes:c:cbwd6|CBWD6]]|0.417|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.416|
|[[:human genes:t:ticrr|TICRR]]|0.416|
|[[:human genes:n:nsf|NSF]]|0.415|
|[[:human genes:a:aqr|AQR]]|0.412|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.412|
|[[:human genes:p:pola2|POLA2]]|0.411|
|[[:human genes:r:rps2|RPS2]]|0.411|
|[[:human genes:r:rpl35|RPL35]]|0.411|
|[[:human genes:r:rad51|RAD51]]|0.41|
|[[:human genes:k:kctd17|KCTD17]]|0.41|
|[[:human genes:p:psmb4|PSMB4]]|0.41|
|[[:human genes:s:syt9|SYT9]]|0.409|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.408|
|[[:human genes:n:nupl1|NUPL1]]|0.407|
|[[:human genes:c:ccdc116|CCDC116]]|0.403|
|[[:human genes:a:acsf2|ACSF2]]|0.403|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.403|
|[[:human genes:n:nup153|NUP153]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 669/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|24/28|
|blood|25/28|
|bone|25/26|
|breast|31/33|
|central nervous system|52/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|14/16|
|kidney|17/21|
|liver|17/20|
|lung|71/75|
|lymphocyte|15/16|
|ovary|23/26|
|pancreas|18/24|
|peripheral nervous system|16/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 386
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDX47 Expression in NALM6 Cells: 6.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>