DDX47

Entrez Summary: N/A
UniProt Summary: Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors. {ECO:0000269|PubMed:15977068, ECO:0000269|PubMed:16963496}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lead acetate 2000μM R08 exp498 no dilution day6	-2.95
Mitomycin-C 0.06μM R08 exp503	-2.22
Actinomycin-D 0.001μM R00 exp3	-2.21
BI-6727 0.04μM R03 exp98	-2.2
RO-3306 3 to 4μM on day4 R04 exp165	1.7
HMS-I2 5μM R06 exp287	1.74
Vincristine 0.0005μM R04 exp190	1.82
Hypoxia 5%O2 R04 exp191	1.85
ABT-702 0.1μM R06 exp260	1.87
ABT-702 5μM R06 exp261	1.89
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.94
BRD2 inhibitor II 20μM R07 exp341	2.02
THZ531 0.11μM R07 exp409	2.02
GW501516 25μM R06 exp285	2.13
proTAME 5μM R04 exp187	2.21
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.23
Apcin 25μM plus proTAME 2μM R04 exp177	2.26

Global Fraction of Cell Lines Where Essential: 669/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	24/28
blood	25/28
bone	25/26
breast	31/33
central nervous system	52/56
cervix	4/4
colorectal	16/17
esophagus	8/13
fibroblast	0/1
gastric	14/16
kidney	17/21
liver	17/20
lung	71/75
lymphocyte	15/16
ovary	23/26
pancreas	18/24
peripheral nervous system	16/16
plasma cell	12/15
prostate	1/1
skin	22/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	26/29
uterus	5/5

Expression Distribution

DEAD
Helicase C

extrinsic apoptotic signaling pathway via death domain receptors
RNA helicase activity
extrinsic apoptotic signaling pathway
rRNA processing
rRNA metabolic process
apoptotic signaling pathway
ribosome biogenesis
ncRNA processing
RNA splicing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
mRNA processing
mRNA metabolic process
nucleolus
RNA processing
apoptotic process
programmed cell death
cell death
RNA binding
ATP binding
RNA metabolic process
membrane
gene expression