DDX6 [The Human Chemical-Genetic Interaction Map Project]

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======= DDX6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDX6
  * **<color #00a2e8>Official Name</color>**: DEAD-box helicase 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1656|1656]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26196|P26196]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDX6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDX6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600326|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573). {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:26098573}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Helicase C|
|DEAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|concave side of sperm head|
|viral RNA genome packaging|
|viral genome packaging|
|outer dense fiber|
|sperm annulus|
|chromatoid body|
|cytoplasmic mRNA processing body assembly|
|RISC complex|
|stress granule assembly|
|heterochromatin|
|exonucleolytic catabolism of deadenylated mRNA|
|helicase activity|
|nuclear-transcribed mRNA catabolic process, exonucleolytic|
|virion assembly|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|RNA helicase activity|
|cytoplasmic stress granule|
|cytoplasmic ribonucleoprotein granule|
|P-body|
|cell-cell adherens junction|
|stem cell population maintenance|
|maintenance of cell number|
|spermatid differentiation|
|mRNA binding|
|nuclear-transcribed mRNA catabolic process|
|viral life cycle|
|mRNA catabolic process|
|negative regulation of neuron differentiation|
|ribonucleoprotein complex assembly|
|protein domain specific binding|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|negative regulation of neurogenesis|
|cadherin binding|
|negative regulation of nervous system development|
|negative regulation of cell development|
|cellular process involved in reproduction in multicellular organism|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|organic cyclic compound catabolic process|
|spermatogenesis|
|male gamete generation|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|gamete generation|
|mRNA metabolic process|
|perinuclear region of cytoplasm|
|viral process|
|negative regulation of cell differentiation|
|organelle assembly|
|symbiotic process|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|nucleolus|
|cellular macromolecule catabolic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|multi-organism reproductive process|
|macromolecule catabolic process|
|negative regulation of multicellular organismal process|
|mitochondrion|
|RNA binding|
|reproductive process|
|reproduction|
|ATP binding|
|generation of neurons|
|protein-containing complex assembly|
|neurogenesis|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.58|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-2.53|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.34|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-2.26|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.12|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.89|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.88|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.85|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.83|
|[[:results:exp302|35°C R06 exp302]]|-1.81|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.75|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.72|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.71|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.7|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.76|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.93|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.23|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:edc3|EDC3]]|0.468|
|[[:human genes:h:hars|HARS]]|0.46|
|[[:human genes:d:dcp2|DCP2]]|0.457|
|[[:human genes:p:pmm2|PMM2]]|0.449|
|[[:human genes:n:nae1|NAE1]]|0.447|
|[[:human genes:g:gnb1l|GNB1L]]|0.444|
|[[:human genes:u:ube2m|UBE2M]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 120/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|5/28|
|bone|5/26|
|breast|6/33|
|central nervous system|10/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|5/21|
|liver|3/20|
|lung|6/75|
|lymphocyte|4/16|
|ovary|3/26|
|pancreas|4/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1505
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDX6 Expression in NALM6 Cells: 8.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>