DEAF1

Entrez Summary: This gene encodes a zinc finger domain-containing protein that functions as a regulator of transcription. The encoded proteins binds to its own promoter as well as to that of several target genes. Activity of this protein is important in the regulation of embryonic development. Mutations in this gene have been found in individuals with autosomal dominant cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zf-MYND
SAND

regulation of mammary gland epithelial cell proliferation
behavioral fear response
behavioral defense response
fear response
visual learning
visual behavior
multicellular organismal response to stress
associative learning
neural tube closure
tube closure
primary neural tube formation
neural tube formation
embryonic epithelial tube formation
embryonic skeletal system development
epithelial tube formation
fibrillar center
morphogenesis of embryonic epithelium
learning
tube formation
neural tube development
transcription factor complex
DNA-binding transcription repressor activity, RNA polymerase II-specific
germ cell development
learning or memory
cognition
response to light stimulus
epithelial tube morphogenesis
RNA polymerase II regulatory region sequence-specific DNA binding
regulation of epithelial cell proliferation
cellular process involved in reproduction in multicellular organism
morphogenesis of an epithelium
response to radiation
transcription by RNA polymerase II
skeletal system development
tissue morphogenesis
embryonic morphogenesis
behavior
chordate embryonic development
transcription, DNA-templated
nucleic acid-templated transcription