DECR1

Entrez Summary: This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq, Jul 2008].
UniProt Summary: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

adh short
KR

2,4-dienoyl-CoA reductase (NADPH) activity
NADPH binding
fatty acid beta-oxidation
fatty acid oxidation
lipid oxidation
protein homotetramerization
fatty acid catabolic process
positive regulation of cold-induced thermogenesis
monocarboxylic acid catabolic process
regulation of cold-induced thermogenesis
protein tetramerization
cellular lipid catabolic process
lipid modification
carboxylic acid catabolic process
organic acid catabolic process
lipid catabolic process
fatty acid metabolic process
protein homooligomerization
mitochondrial matrix
small molecule catabolic process
protein complex oligomerization
monocarboxylic acid metabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
mitochondrion
protein-containing complex assembly
positive regulation of multicellular organismal process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process
protein-containing complex subunit organization