DECR2

Entrez Summary: N/A
UniProt Summary: Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19- docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

adh short
KR

2,4-dienoyl-CoA reductase (NADPH) activity
trans-2-enoyl-CoA reductase (NADPH) activity
fatty acid beta-oxidation using acyl-CoA oxidase
unsaturated fatty acid biosynthetic process
fatty acid beta-oxidation
peroxisomal membrane
protein localization to peroxisome
protein targeting to peroxisome
establishment of protein localization to peroxisome
peroxisomal transport
fatty acid oxidation
lipid oxidation
peroxisome organization
fatty acid catabolic process
unsaturated fatty acid metabolic process
monocarboxylic acid catabolic process
fatty acid biosynthetic process
monocarboxylic acid biosynthetic process
cellular lipid catabolic process
lipid modification
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
protein targeting
establishment of protein localization to organelle
small molecule catabolic process
monocarboxylic acid metabolic process
lipid biosynthetic process
small molecule biosynthetic process
protein localization to organelle
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process
intracellular protein transport
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process