DEDD2

Entrez Summary: N/A
UniProt Summary: May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

rRNA catabolic process
receptor signaling complex adaptor activity
apoptotic nuclear changes
cellular component disassembly involved in execution phase of apoptosis
ncRNA catabolic process
extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of extrinsic apoptotic signaling pathway
execution phase of apoptosis
extrinsic apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway
positive regulation of apoptotic signaling pathway
rRNA metabolic process
RNA catabolic process
apoptotic signaling pathway
nucleobase-containing compound catabolic process
regulation of apoptotic signaling pathway
cellular component disassembly
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
ncRNA metabolic process
organic cyclic compound catabolic process
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
nucleolus
RNA processing
cellular homeostasis
cellular macromolecule catabolic process
apoptotic process
macromolecule catabolic process
programmed cell death
cell death
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding