DEFA1 [The Human Chemical-Genetic Interaction Map Project]

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======= DEFA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DEFA1
  * **<color #00a2e8>Official Name</color>**: defensin alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1667|1667]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P59665|P59665]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DEFA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DEFA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/125220|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. {ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:17452329}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Defensin propep|
|Defensin 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|modification by symbiont of host structure|
|modification of cellular component in other organism involved in symbiotic interaction|
|modification by organism of membrane in other organism involved in symbiotic interaction|
|modification of structure of other organism involved in symbiotic interaction|
|modification by symbiont of host cell membrane|
|modification by symbiont of host cellular component|
|pore formation in membrane of other organism during symbiotic interaction|
|pore formation in membrane of other organism|
|membrane disruption in other organism|
|disruption by host of symbiont cells|
|T cell chemotaxis|
|disruption of cells of other organism involved in symbiotic interaction|
|innate immune response in mucosa|
|intracellular estrogen receptor signaling pathway|
|defense response to protozoan|
|response to protozoan|
|T cell migration|
|mucosal immune response|
|organ or tissue specific immune response|
|defense response to fungus|
|antibacterial humoral response|
|modification by symbiont of host morphology or physiology|
|lymphocyte chemotaxis|
|response to fungus|
|disruption of cells of other organism|
|killing of cells of other organism|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|lymphocyte migration|
|intracellular steroid hormone receptor signaling pathway|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|defense response to Gram-negative bacterium|
|cell killing|
|azurophil granule lumen|
|defense response to Gram-positive bacterium|
|Golgi lumen|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|antimicrobial humoral response|
|steroid hormone mediated signaling pathway|
|leukocyte chemotaxis|
|modification of morphology or physiology of other organism|
|interaction with host|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|cellular response to lipopolysaccharide|
|cellular response to steroid hormone stimulus|
|cellular response to molecule of bacterial origin|
|defense response to virus|
|cell chemotaxis|
|cellular response to biotic stimulus|
|response to virus|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|response to steroid hormone|
|defense response to bacterium|
|humoral immune response|
|collagen-containing extracellular matrix|
|leukocyte migration|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|cellular response to lipid|
|myeloid cell activation involved in immune response|
|cellular response to organic cyclic compound|
|chemotaxis|
|taxis|
|myeloid leukocyte activation|
|cellular response to hormone stimulus|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|response to bacterium|
|regulated exocytosis|
|innate immune response|
|leukocyte mediated immunity|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|leukocyte activation|
|defense response to other organism|
|cell migration|
|secretion by cell|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|secretion|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|extracellular space|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14167
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DEFA1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>