DEFA3

Entrez Summary: N/A
UniProt Summary: Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. {ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:15894545, ECO:0000269|PubMed:17452329, ECO:0000269|PubMed:2006422}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

Defensin 1
Defensin propep

membrane disruption in other organism
innate immune response in mucosa
intracellular estrogen receptor signaling pathway
mucosal immune response
organ or tissue specific immune response
defense response to fungus
antibacterial humoral response
response to fungus
killing of cells of other organism
disruption of cells of other organism
antimicrobial humoral immune response mediated by antimicrobial peptide
intracellular steroid hormone receptor signaling pathway
defense response to Gram-negative bacterium
cell killing
azurophil granule lumen
defense response to Gram-positive bacterium
Golgi lumen
antimicrobial humoral response
steroid hormone mediated signaling pathway
modification of morphology or physiology of other organism
intracellular receptor signaling pathway
hormone-mediated signaling pathway
cellular response to lipopolysaccharide
cellular response to steroid hormone stimulus
defense response to virus
cellular response to molecule of bacterial origin
cellular response to biotic stimulus
response to virus
response to lipopolysaccharide
response to molecule of bacterial origin
response to steroid hormone
defense response to bacterium
humoral immune response
cellular response to lipid
cellular response to organic cyclic compound
cellular response to hormone stimulus
response to bacterium
molecular function
innate immune response
interspecies interaction between organisms