DEFA5

Entrez Summary: N/A
UniProt Summary: Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:17088326}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Defensin propep
Defensin 1

membrane disruption in other organism
innate immune response in mucosa
positive regulation of membrane permeability
mucosal immune response
organ or tissue specific immune response
defense response to fungus
antibacterial humoral response
response to fungus
killing of cells of other organism
disruption of cells of other organism
antimicrobial humoral immune response mediated by antimicrobial peptide
regulation of membrane permeability
defense response to Gram-negative bacterium
cell killing
transport vesicle
defense response to Gram-positive bacterium
Golgi lumen
antimicrobial humoral response
secretory granule lumen
modification of morphology or physiology of other organism
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
cellular response to biotic stimulus
response to lipopolysaccharide
response to molecule of bacterial origin
defense response to bacterium
humoral immune response
cellular response to lipid
response to bacterium
innate immune response
interspecies interaction between organisms
response to lipid
protein homodimerization activity
defense response to other organism
cellular response to oxygen-containing compound
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
response to oxygen-containing compound