DEFB1 [The Human Chemical-Genetic Interaction Map Project]

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======= DEFB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DEFB1
  * **<color #00a2e8>Official Name</color>**: defensin beta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1672|1672]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60022|P60022]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DEFB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DEFB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602056|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636). {ECO:0000269|PubMed:25122636}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Defensin beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of flagellated sperm motility involved in capacitation|
|microvesicle|
|CCR6 chemokine receptor binding|
|positive regulation of cilium-dependent cell motility|
|positive regulation of flagellated sperm motility|
|regulation of flagellated sperm motility|
|innate immune response in mucosa|
|sperm midpiece|
|regulation of cilium-dependent cell motility|
|calcium-mediated signaling using intracellular calcium source|
|sperm capacitation|
|mucosal immune response|
|organ or tissue specific immune response|
|antibacterial humoral response|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|extrinsic component of membrane|
|positive regulation of reproductive process|
|defense response to Gram-negative bacterium|
|defense response to Gram-positive bacterium|
|Golgi lumen|
|antimicrobial humoral response|
|calcium-mediated signaling|
|cAMP-mediated signaling|
|spermatid development|
|spermatid differentiation|
|cell maturation|
|regulation of reproductive process|
|cyclic-nucleotide-mediated signaling|
|developmental maturation|
|germ cell development|
|defense response to bacterium|
|second-messenger-mediated signaling|
|humoral immune response|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|spermatogenesis|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|male gamete generation|
|developmental process involved in reproduction|
|response to bacterium|
|gamete generation|
|innate immune response|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of cell motility|
|defense response to other organism|
|regulation of locomotion|
|regulation of cellular component movement|
|multi-organism reproductive process|
|identical protein binding|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|reproductive process|
|reproduction|
|extracellular space|
|cell development|
|intracellular signal transduction|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16402
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DEFB1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>