DEFB1

Entrez Summary: N/A
UniProt Summary: Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636). {ECO:0000269|PubMed:25122636}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of flagellated sperm motility involved in capacitation
microvesicle
CCR6 chemokine receptor binding
positive regulation of cilium-dependent cell motility
positive regulation of flagellated sperm motility
regulation of flagellated sperm motility
innate immune response in mucosa
sperm midpiece
regulation of cilium-dependent cell motility
calcium-mediated signaling using intracellular calcium source
sperm capacitation
mucosal immune response
organ or tissue specific immune response
antibacterial humoral response
antimicrobial humoral immune response mediated by antimicrobial peptide
extrinsic component of membrane
positive regulation of reproductive process
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
Golgi lumen
antimicrobial humoral response
calcium-mediated signaling
cAMP-mediated signaling
spermatid development
spermatid differentiation
cell maturation
regulation of reproductive process
cyclic-nucleotide-mediated signaling
developmental maturation
germ cell development
defense response to bacterium
second-messenger-mediated signaling
humoral immune response
cellular process involved in reproduction in multicellular organism
positive regulation of cell motility
positive regulation of cellular component movement
spermatogenesis
chemotaxis
taxis
positive regulation of locomotion