DEFB4A

• Official Symbol: DEFB4A
• Official Name: defensin beta 4A
• Aliases and Previous Symbols: N/A
• Entrez ID: 1673
• UniProt: O15263
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Jul 2008].
• UniProt Summary: Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells (PubMed:20068036). {ECO:0000269|PubMed:20068036}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 6442
• Expression level (log2 read counts): -7.68

Expression Distribution

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DEFB4A Expression in NALM6 Cells: -7.68