DEGS2

Entrez Summary: N/A
UniProt Summary: Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. {ECO:0000269|PubMed:15063729}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

FA desaturase
Lipid DES

sphingosine hydroxylase activity
sphingolipid delta-4 desaturase activity
sphinganine metabolic process
sphingoid metabolic process
diol metabolic process
ceramide biosynthetic process
ceramide metabolic process
sphingolipid biosynthetic process
polyol metabolic process
membrane lipid biosynthetic process
sphingolipid metabolic process
ammonium ion metabolic process
membrane lipid metabolic process
alcohol metabolic process
organic hydroxy compound metabolic process
amide biosynthetic process
lipid biosynthetic process
cellular amide metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
oxidation-reduction process
lipid metabolic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
small molecule metabolic process