DENND1B

Entrez Summary: N/A
UniProt Summary: Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin- mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down- modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163, ECO:0000269|PubMed:26774822}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

T-helper 2 cell cytokine production
CD4-positive, alpha-beta T cell cytokine production
type 2 immune response
T cell cytokine production
phosphatidylinositol phosphate binding
cytokine production involved in immune response
endocytic recycling
Rab guanyl-nucleotide exchange factor activity
T cell mediated immunity
clathrin-coated vesicle
cytokine production
Rab GTPase binding
T cell receptor signaling pathway
production of molecular mediator of immune response
endosomal transport
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
antigen receptor-mediated signaling pathway
nuclear speck
positive regulation of GTPase activity
immune response-activating cell surface receptor signaling pathway
immune response-regulating cell surface receptor signaling pathway
regulation of GTPase activity
endocytosis
immune response-activating signal transduction
immune response-regulating signaling pathway
adaptive immune response
activation of immune response
import into cell
intracellular membrane-bounded organelle
leukocyte mediated immunity
positive regulation of hydrolase activity
positive regulation of immune response
immune effector process
positive regulation of immune system process
regulation of immune response
regulation of hydrolase activity
positive regulation of catalytic activity
protein transport
intracellular transport