DERA [The Human Chemical-Genetic Interaction Map Project]

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======= DERA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DERA
  * **<color #00a2e8>Official Name</color>**: deoxyribose-phosphate aldolase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51071|51071]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y315|Q9Y315]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DERA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DERA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619668|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation. {ECO:0000269|PubMed:25229427}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DeoC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|deoxyribose-phosphate aldolase activity|
|deoxyribonucleoside catabolic process|
|deoxyribonucleoside metabolic process|
|pentose-phosphate shunt|
|NADPH regeneration|
|deoxyribonucleotide catabolic process|
|deoxyribose phosphate catabolic process|
|glucose 6-phosphate metabolic process|
|NADP metabolic process|
|deoxyribose phosphate metabolic process|
|deoxyribonucleotide metabolic process|
|nucleoside catabolic process|
|glycosyl compound catabolic process|
|nucleobase-containing small molecule catabolic process|
|nucleotide catabolic process|
|nucleoside phosphate catabolic process|
|nucleobase-containing small molecule biosynthetic process|
|nucleoside metabolic process|
|secretory granule lumen|
|carbohydrate catabolic process|
|ficolin-1-rich granule lumen|
|organophosphate catabolic process|
|glycosyl compound metabolic process|
|carbohydrate derivative catabolic process|
|nucleobase-containing compound catabolic process|
|generation of precursor metabolites and energy|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|carbohydrate metabolic process|
|organic cyclic compound catabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|nucleobase-containing small molecule metabolic process|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|organophosphate metabolic process|
|leukocyte activation|
|oxidation-reduction process|
|secretion by cell|
|carbohydrate derivative metabolic process|
|export from cell|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|nucleobase-containing compound biosynthetic process|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-3.72|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.3|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-2.19|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.88|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.79|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.72|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.72|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.81|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.82|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.94|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18082
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DERA Expression in NALM6 Cells: 4.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>