DERA

Entrez Summary: N/A
UniProt Summary: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation. {ECO:0000269|PubMed:25229427}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

deoxyribose-phosphate aldolase activity
deoxyribonucleoside catabolic process
deoxyribonucleoside metabolic process
pentose-phosphate shunt
NADPH regeneration
deoxyribonucleotide catabolic process
deoxyribose phosphate catabolic process
glucose 6-phosphate metabolic process
NADP metabolic process
deoxyribose phosphate metabolic process
deoxyribonucleotide metabolic process
nucleoside catabolic process
glycosyl compound catabolic process
nucleobase-containing small molecule catabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
nucleobase-containing small molecule biosynthetic process
nucleoside metabolic process
secretory granule lumen
carbohydrate catabolic process
ficolin-1-rich granule lumen
organophosphate catabolic process
glycosyl compound metabolic process
carbohydrate derivative catabolic process
nucleobase-containing compound catabolic process
generation of precursor metabolites and energy
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
carbohydrate metabolic process
organic cyclic compound catabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation