DERL3

Gene Information

Official Symbol: DERL3
Official Name: derlin 3
Aliases and Previous Symbols: N/A
Entrez ID: 91319
UniProt: Q96Q80
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins (PubMed:16449189, PubMed:22607976). May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). {ECO:0000269|PubMed:16449189, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:26565908}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6514
Expression level (log2 read counts): 4.87

Expression Distribution

signal recognition particle
signal recognition particle receptor complex
Hrd1p ubiquitin ligase ERAD-L complex
negative regulation of retrograde protein transport, ER to cytosol
negative regulation of protein exit from endoplasmic reticulum
regulation of retrograde protein transport, ER to cytosol
negative regulation of ERAD pathway
ubiquitin-specific protease binding
regulation of protein exit from endoplasmic reticulum
misfolded protein binding
regulation of ERAD pathway
protein N-linked glycosylation via asparagine
peptidyl-asparagine modification
negative regulation of intracellular protein transport
negative regulation of response to endoplasmic reticulum stress
negative regulation of proteasomal protein catabolic process
negative regulation of intracellular transport
ubiquitin-dependent ERAD pathway
negative regulation of proteolysis involved in cellular protein catabolic process
protein N-linked glycosylation
regulation of response to endoplasmic reticulum stress
negative regulation of cellular protein catabolic process
ERAD pathway
endoplasmic reticulum unfolded protein response
integral component of endoplasmic reticulum membrane
negative regulation of cellular protein localization
cellular response to unfolded protein
negative regulation of protein catabolic process
cellular response to topologically incorrect protein
response to unfolded protein
negative regulation of protein transport
regulation of proteasomal protein catabolic process
negative regulation of establishment of protein localization
response to topologically incorrect protein
regulation of proteolysis involved in cellular protein catabolic process
regulation of intracellular protein transport
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
macromolecule glycosylation
response to endoplasmic reticulum stress