DGKA

Entrez Summary: N/A
UniProt Summary: Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

diacylglycerol kinase activity
NAD+ kinase activity
diacylglycerol metabolic process
protein kinase C-activating G protein-coupled receptor signaling pathway
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
lipid phosphorylation
kinase activity
acylglycerol metabolic process
neutral lipid metabolic process
phospholipid binding
platelet activation
lipid modification
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
blood coagulation
coagulation
hemostasis
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
wound healing
regulation of body fluid levels
organophosphate biosynthetic process
response to wounding
lipid biosynthetic process
calcium ion binding
organophosphate metabolic process
cellular lipid metabolic process
cell activation
lipid metabolic process
phosphorylation
G protein-coupled receptor signaling pathway
ATP binding
intracellular signal transduction
membrane