DGKG

Entrez Summary: N/A
UniProt Summary: Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rucaparib 6.5μM R08 exp520	-1.82
Cadmium 60μM R08 exp462	1.87

diacylglycerol kinase activity
NAD+ kinase activity
diacylglycerol metabolic process
protein kinase C-activating G protein-coupled receptor signaling pathway
lipid phosphorylation
acylglycerol metabolic process
neutral lipid metabolic process
platelet activation
lipid modification
blood coagulation
coagulation
hemostasis
glycerolipid metabolic process
wound healing
regulation of body fluid levels
response to wounding
calcium ion binding
neuron development
cellular lipid metabolic process
neuron differentiation
cell activation
lipid metabolic process
phosphorylation
G protein-coupled receptor signaling pathway
ATP binding
generation of neurons
neurogenesis
cell development
intracellular signal transduction