DGKK [The Human Chemical-Genetic Interaction Map Project]

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======= DGKK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DGKK
  * **<color #00a2e8>Official Name</color>**: diacylglycerol kinase kappa
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=139189|139189]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5KSL6|Q5KSL6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DGKK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DGKK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300837|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). {ECO:0000269|PubMed:16210324}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DAGK cat|
|C1 1|
|DAGK acc|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|diacylglycerol kinase activity|
|NAD+ kinase activity|
|diacylglycerol metabolic process|
|protein kinase C-activating G protein-coupled receptor signaling pathway|
|lipid phosphorylation|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|platelet activation|
|lipid modification|
|blood coagulation|
|coagulation|
|hemostasis|
|glycerolipid metabolic process|
|response to oxidative stress|
|wound healing|
|regulation of body fluid levels|
|response to wounding|
|cellular lipid metabolic process|
|cell activation|
|lipid metabolic process|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|ATP binding|
|intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-2.5|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.83|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18134
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DGKK Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>