DGKK

Entrez Summary: The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011].
UniProt Summary: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). {ECO:0000269|PubMed:16210324}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

diacylglycerol kinase activity
NAD+ kinase activity
diacylglycerol metabolic process
protein kinase C-activating G protein-coupled receptor signaling pathway
lipid phosphorylation
acylglycerol metabolic process
neutral lipid metabolic process
platelet activation
lipid modification
blood coagulation
coagulation
hemostasis
glycerolipid metabolic process
response to oxidative stress
wound healing
regulation of body fluid levels
response to wounding
cellular lipid metabolic process
cell activation
lipid metabolic process
phosphorylation
G protein-coupled receptor signaling pathway
ATP binding
intracellular signal transduction