DGUOK

Gene Information

Official Symbol: DGUOK
Official Name: deoxyguanosine kinase
Aliases and Previous Symbols: N/A
Entrez ID: 1716
UniProt: Q16854
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents. {ECO:0000269|PubMed:11687801, ECO:0000269|PubMed:17073823, ECO:0000269|PubMed:23043144, ECO:0000269|PubMed:8706825}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18502
Expression level (log2 read counts): 4.89

Expression Distribution

deoxyguanosine kinase activity
guanosine metabolic process
purine deoxyribonucleoside metabolic process
deoxynucleoside kinase activity
dGTP metabolic process
deoxyribonucleoside metabolic process
purine deoxyribonucleoside triphosphate metabolic process
deoxyribonucleoside monophosphate biosynthetic process
purine deoxyribonucleotide metabolic process
deoxyribonucleoside monophosphate metabolic process
purine-containing compound salvage
deoxyribonucleoside triphosphate metabolic process
2-deoxyribonucleotide metabolic process
deoxyribose phosphate metabolic process
deoxyribonucleotide metabolic process
cellular metabolic compound salvage
guanosine-containing compound metabolic process
nucleoside monophosphate biosynthetic process
purine ribonucleoside metabolic process
purine nucleoside metabolic process
purine nucleoside triphosphate metabolic process
nucleoside monophosphate metabolic process
ribonucleoside metabolic process
nucleoside triphosphate metabolic process
nucleoside metabolic process
glycosyl compound metabolic process
negative regulation of neuron projection development
purine-containing compound biosynthetic process
negative regulation of cell projection organization
negative regulation of neuron differentiation
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
negative regulation of neurogenesis
negative regulation of nervous system development
purine nucleotide metabolic process
negative regulation of cell development
purine-containing compound metabolic process
mitochondrial matrix
nucleotide metabolic process
nucleoside phosphate metabolic process