DHDDS [The Human Chemical-Genetic Interaction Map Project]

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======= DHDDS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DHDDS
  * **<color #00a2e8>Official Name</color>**: dehydrodolichyl diphosphate synthase subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79947|79947]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86SQ9|Q86SQ9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DHDDS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DHDDS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608172|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Prenyltransf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polyprenyltransferase activity|
|dehydrodolichyl diphosphate synthase activity|
|dehydrodolichyl diphosphate synthase complex|
|polyprenol biosynthetic process|
|dolichyl diphosphate metabolic process|
|dolichyl diphosphate biosynthetic process|
|polyprenol metabolic process|
|dolichol-linked oligosaccharide biosynthetic process|
|oligosaccharide-lipid intermediate biosynthetic process|
|isoprenoid biosynthetic process|
|protein N-linked glycosylation|
|alcohol biosynthetic process|
|isoprenoid metabolic process|
|organic hydroxy compound biosynthetic process|
|phospholipid biosynthetic process|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|alcohol metabolic process|
|glycoprotein biosynthetic process|
|phospholipid metabolic process|
|glycoprotein metabolic process|
|organic hydroxy compound metabolic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.14|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-2.08|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.93|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.87|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.8|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.75|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.72|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.75|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.82|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.11|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.562|
|[[:human genes:h:hspd1|HSPD1]]|0.542|
|[[:human genes:r:rnmt|RNMT]]|0.531|
|[[:human genes:g:gfpt1|GFPT1]]|0.526|
|[[:human genes:p:polr3h|POLR3H]]|0.499|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.499|
|[[:human genes:e:eif4e|EIF4E]]|0.494|
|[[:human genes:s:spcs3|SPCS3]]|0.493|
|[[:human genes:u:uap1|UAP1]]|0.491|
|[[:human genes:s:srp72|SRP72]]|0.476|
|[[:human genes:d:dpagt1|DPAGT1]]|0.471|
|[[:human genes:r:rtcb|RTCB]]|0.467|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.46|
|[[:human genes:g:gmppb|GMPPB]]|0.457|
|[[:human genes:t:tbca|TBCA]]|0.456|
|[[:human genes:o:osgep|OSGEP]]|0.453|
|[[:human genes:a:alg13|ALG13]]|0.448|
|[[:human genes:d:dad1|DAD1]]|0.448|
|[[:human genes:c:ccdc101|CCDC101]]|0.445|
|[[:human genes:g:gnb1l|GNB1L]]|0.444|
|[[:human genes:v:vmp1|VMP1]]|0.443|
|[[:human genes:a:aars|AARS]]|0.443|
|[[:human genes:s:spcs2|SPCS2]]|0.443|
|[[:human genes:r:rptor|RPTOR]]|0.437|
|[[:human genes:s:slc35b1|SLC35B1]]|0.435|
|[[:human genes:t:thg1l|THG1L]]|0.432|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.426|
|[[:human genes:t:tti2|TTI2]]|0.426|
|[[:human genes:n:nae1|NAE1]]|0.425|
|[[:human genes:a:alg2|ALG2]]|0.424|
|[[:human genes:z:znf259|ZNF259]]|0.423|
|[[:human genes:p:pelo|PELO]]|0.423|
|[[:human genes:c:cbfb|CBFB]]|0.422|
|[[:human genes:a:alg5|ALG5]]|0.421|
|[[:human genes:m:meaf6|MEAF6]]|0.42|
|[[:human genes:n:nars|NARS]]|0.419|
|[[:human genes:t:tmem41b|TMEM41B]]|0.419|
|[[:human genes:g:gtf3a|GTF3A]]|0.419|
|[[:human genes:p:pmm2|PMM2]]|0.417|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.416|
|[[:human genes:e:eny2|ENY2]]|0.414|
|[[:human genes:p:pmpcb|PMPCB]]|0.414|
|[[:human genes:m:mtor|MTOR]]|0.413|
|[[:human genes:c:cep350|CEP350]]|0.412|
|[[:human genes:s:srp14|SRP14]]|0.409|
|[[:human genes:h:haus8|HAUS8]]|0.409|
|[[:human genes:a:alg1|ALG1]]|0.408|
|[[:human genes:m:med16|MED16]]|0.408|
|[[:human genes:o:otud5|OTUD5]]|0.408|
|[[:human genes:n:nsmce1|NSMCE1]]|0.405|
|[[:human genes:a:alg14|ALG14]]|0.404|
|[[:human genes:d:dnajc3|DNAJC3]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 733/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 101
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DHDDS Expression in NALM6 Cells: 5.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>