DHDDS

Entrez Summary: The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 733/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	55/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	20/21
liver	20/20
lung	74/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	5/5

Expression Distribution

polyprenyltransferase activity
dehydrodolichyl diphosphate synthase activity
dehydrodolichyl diphosphate synthase complex
polyprenol biosynthetic process
dolichyl diphosphate metabolic process
dolichyl diphosphate biosynthetic process
polyprenol metabolic process
dolichol-linked oligosaccharide biosynthetic process
oligosaccharide-lipid intermediate biosynthetic process
isoprenoid biosynthetic process
protein N-linked glycosylation
alcohol biosynthetic process
isoprenoid metabolic process
organic hydroxy compound biosynthetic process
phospholipid biosynthetic process
protein glycosylation
macromolecule glycosylation
glycosylation
alcohol metabolic process
glycoprotein biosynthetic process
phospholipid metabolic process
glycoprotein metabolic process
organic hydroxy compound metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
small molecule biosynthetic process
carbohydrate derivative biosynthetic process
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
endoplasmic reticulum
carbohydrate derivative metabolic process
lipid metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process