DHODH [The Human Chemical-Genetic Interaction Map Project]

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======= DHODH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DHODH
  * **<color #00a2e8>Official Name</color>**: dihydroorotate dehydrogenase (quinone)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1723|1723]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02127|Q02127]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DHODH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DHODH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/126064|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DHO dh|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dihydroorotate dehydrogenase activity|
|de novo UMP biosynthetic process|
|response to L-arginine|
|de novo pyrimidine nucleobase biosynthetic process|
|pyrimidine nucleobase biosynthetic process|
|ubiquinone binding|
|UMP metabolic process|
|pyrimidine ribonucleoside monophosphate metabolic process|
|UMP biosynthetic process|
|pyrimidine ribonucleoside monophosphate biosynthetic process|
|pyrimidine nucleoside monophosphate biosynthetic process|
|FMN binding|
|pyrimidine nucleoside biosynthetic process|
|response to caffeine|
|pyrimidine nucleoside monophosphate metabolic process|
|response to diuretic|
|nucleobase biosynthetic process|
|pyrimidine ribonucleotide biosynthetic process|
|pyrimidine nucleobase metabolic process|
|regulation of mitochondrial fission|
|pyrimidine ribonucleotide metabolic process|
|ribonucleoside monophosphate biosynthetic process|
|pyrimidine nucleoside metabolic process|
|nucleoside biosynthetic process|
|glycosyl compound biosynthetic process|
|nucleobase metabolic process|
|nucleoside monophosphate biosynthetic process|
|lactation|
|pyrimidine nucleotide biosynthetic process|
|ribonucleoside monophosphate metabolic process|
|pyrimidine-containing compound biosynthetic process|
|drug binding|
|pyrimidine nucleotide metabolic process|
|nucleoside monophosphate metabolic process|
|body fluid secretion|
|pyrimidine-containing compound metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|nucleoside metabolic process|
|response to alkaloid|
|response to amino acid|
|mammary gland development|
|glycosyl compound metabolic process|
|response to purine-containing compound|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|regulation of mitochondrion organization|
|female pregnancy|
|response to starvation|
|multi-multicellular organism process|
|response to nutrient|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|response to xenobiotic stimulus|
|ribonucleotide metabolic process|
|ribose phosphate metabolic process|
|response to acid chemical|
|neuronal cell body|
|mitochondrial inner membrane|
|gland development|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|regulation of body fluid levels|
|response to nutrient levels|
|response to extracellular stimulus|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|organophosphate metabolic process|
|response to organic cyclic compound|
|oxidation-reduction process|
|multi-organism reproductive process|
|response to organonitrogen compound|
|response to drug|
|carbohydrate derivative metabolic process|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular nitrogen compound biosynthetic process|
|regulation of cell death|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.37|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.7|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.83|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.85|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 63/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|10/28|
|bone|2/26|
|breast|4/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|4/75|
|lymphocyte|3/16|
|ovary|1/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 163
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DHODH Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>