DHODH

Entrez Summary: The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 63/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	10/28
bone	2/26
breast	4/33
central nervous system	1/56
cervix	0/4
colorectal	1/17
esophagus	2/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	1/20
lung	4/75
lymphocyte	3/16
ovary	1/26
pancreas	3/24
peripheral nervous system	1/16
plasma cell	4/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	1/5

Expression Distribution

dihydroorotate dehydrogenase activity
de novo UMP biosynthetic process
response to L-arginine
de novo pyrimidine nucleobase biosynthetic process
pyrimidine nucleobase biosynthetic process
ubiquinone binding
UMP metabolic process
pyrimidine ribonucleoside monophosphate metabolic process
UMP biosynthetic process
pyrimidine ribonucleoside monophosphate biosynthetic process
pyrimidine nucleoside monophosphate biosynthetic process
FMN binding
pyrimidine nucleoside biosynthetic process
response to caffeine
pyrimidine nucleoside monophosphate metabolic process
response to diuretic
nucleobase biosynthetic process
pyrimidine ribonucleotide biosynthetic process
pyrimidine nucleobase metabolic process
regulation of mitochondrial fission
pyrimidine ribonucleotide metabolic process
ribonucleoside monophosphate biosynthetic process
pyrimidine nucleoside metabolic process
nucleoside biosynthetic process
glycosyl compound biosynthetic process
nucleobase metabolic process
nucleoside monophosphate biosynthetic process
lactation
pyrimidine nucleotide biosynthetic process
ribonucleoside monophosphate metabolic process
pyrimidine-containing compound biosynthetic process
drug binding
pyrimidine nucleotide metabolic process
nucleoside monophosphate metabolic process
body fluid secretion
pyrimidine-containing compound metabolic process
nucleobase-containing small molecule biosynthetic process
nucleoside metabolic process
response to alkaloid
response to amino acid