DHRS2 [The Human Chemical-Genetic Interaction Map Project]

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======= DHRS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DHRS2
  * **<color #00a2e8>Official Name</color>**: dehydrogenase/reductase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10202|10202]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13268|Q13268]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DHRS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DHRS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615194|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21. {ECO:0000269|PubMed:16685466, ECO:0000269|PubMed:20547751}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KR|
|adh short|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|carbonyl reductase (NADPH) activity|
|myeloid dendritic cell differentiation|
|myeloid dendritic cell activation|
|C21-steroid hormone metabolic process|
|dendritic cell differentiation|
|myeloid leukocyte differentiation|
|cellular hormone metabolic process|
|nuclear envelope|
|hormone metabolic process|
|myeloid cell differentiation|
|cellular response to oxidative stress|
|steroid metabolic process|
|leukocyte differentiation|
|mitochondrial matrix|
|response to oxidative stress|
|response to toxic substance|
|regulation of hormone levels|
|hemopoiesis|
|myeloid leukocyte activation|
|hematopoietic or lymphoid organ development|
|immune system development|
|negative regulation of cell population proliferation|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|leukocyte activation|
|oxidation-reduction process|
|negative regulation of cell death|
|cell activation|
|lipid metabolic process|
|mitochondrion|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|regulation of cell death|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13605
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DHRS2 Expression in NALM6 Cells: 2.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>