DHRS2

Entrez Summary: N/A
UniProt Summary: Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21. {ECO:0000269|PubMed:16685466, ECO:0000269|PubMed:20547751}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

KR
adh short

carbonyl reductase (NADPH) activity
myeloid dendritic cell differentiation
myeloid dendritic cell activation
C21-steroid hormone metabolic process
dendritic cell differentiation
myeloid leukocyte differentiation
cellular hormone metabolic process
nuclear envelope
hormone metabolic process
myeloid cell differentiation
cellular response to oxidative stress
steroid metabolic process
leukocyte differentiation
mitochondrial matrix
response to oxidative stress
response to toxic substance
regulation of hormone levels
hemopoiesis
myeloid leukocyte activation
hematopoietic or lymphoid organ development
immune system development
negative regulation of cell population proliferation
negative regulation of apoptotic process
negative regulation of programmed cell death
leukocyte activation
oxidation-reduction process
negative regulation of cell death
cell activation
lipid metabolic process
mitochondrion
regulation of apoptotic process
regulation of programmed cell death
regulation of cell population proliferation
regulation of cell death
cellular response to stress