DHRS9

Entrez Summary: N/A
UniProt Summary: 3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH. {ECO:0000269|PubMed:11294878, ECO:0000269|PubMed:11304534, ECO:0000269|PubMed:12618084}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

racemase and epimerase activity
androstan-3-alpha,17-beta-diol dehydrogenase activity
9-cis-retinoic acid biosynthetic process
9-cis-retinoic acid metabolic process
androsterone dehydrogenase activity
testosterone dehydrogenase (NAD+) activity
alcohol dehydrogenase (NAD) activity
retinoic acid biosynthetic process
diterpenoid biosynthetic process
progesterone metabolic process
terpenoid biosynthetic process
retinol dehydrogenase activity
androgen metabolic process
isoprenoid biosynthetic process
C21-steroid hormone metabolic process
retinoic acid metabolic process
retinol metabolic process
cellular ketone metabolic process
primary alcohol metabolic process
retinoid metabolic process
integral component of endoplasmic reticulum membrane
diterpenoid metabolic process
terpenoid metabolic process
cellular hormone metabolic process
isoprenoid metabolic process
monocarboxylic acid biosynthetic process
hormone metabolic process
steroid metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
alcohol metabolic process
organic hydroxy compound metabolic process
drug metabolic process
monocarboxylic acid metabolic process
regulation of hormone levels
lipid biosynthetic process
small molecule biosynthetic process
epithelial cell differentiation
carboxylic acid metabolic process
endoplasmic reticulum membrane