DHTKD1 [The Human Chemical-Genetic Interaction Map Project]

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======= DHTKD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DHTKD1
  * **<color #00a2e8>Official Name</color>**: dehydrogenase E1 and transketolase domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55526|55526]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96HY7|Q96HY7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DHTKD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DHTKD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614984|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of a mitochondrial 2-oxoglutarate-dehydrogenase-complex-like protein involved in the degradation pathways of several amino acids, including lysine. Mutations in this gene are associated with 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth Disease Type 2Q. [provided by RefSeq, May 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Transket pyr|
|E1 dh|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oxoglutarate dehydrogenase (succinyl-transferring) activity|
|thiamine pyrophosphate binding|
|oxoglutarate dehydrogenase complex|
|tricarboxylic acid cycle|
|glycolytic process|
|ATP generation from ADP|
|ADP metabolic process|
|nucleoside diphosphate phosphorylation|
|purine ribonucleoside diphosphate metabolic process|
|nucleotide phosphorylation|
|purine nucleoside diphosphate metabolic process|
|ribonucleoside diphosphate metabolic process|
|pyruvate metabolic process|
|aerobic respiration|
|nucleoside diphosphate metabolic process|
|hematopoietic progenitor cell differentiation|
|carbohydrate catabolic process|
|cellular respiration|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|generation of precursor metabolites and energy|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|carbohydrate metabolic process|
|monocarboxylic acid metabolic process|
|nucleobase-containing small molecule metabolic process|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|mitochondrion|
|phosphorylation|
|small molecule metabolic process|
|organic substance catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.87|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.8|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12154
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DHTKD1 Expression in NALM6 Cells: 5.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>