DHTKD1

Entrez Summary: This gene encodes a component of a mitochondrial 2-oxoglutarate-dehydrogenase-complex-like protein involved in the degradation pathways of several amino acids, including lysine. Mutations in this gene are associated with 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth Disease Type 2Q. [provided by RefSeq, May 2013].
UniProt Summary: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
IU1-47 25μM R04 exp182	-1.87
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.8
ABT-702 0.1μM R06 exp260	-1.75

Transket pyr
E1 dh

oxoglutarate dehydrogenase (succinyl-transferring) activity
thiamine pyrophosphate binding
oxoglutarate dehydrogenase complex
tricarboxylic acid cycle
glycolytic process
ATP generation from ADP
ADP metabolic process
nucleoside diphosphate phosphorylation
purine ribonucleoside diphosphate metabolic process
nucleotide phosphorylation
purine nucleoside diphosphate metabolic process
ribonucleoside diphosphate metabolic process
pyruvate metabolic process
aerobic respiration
nucleoside diphosphate metabolic process
hematopoietic progenitor cell differentiation
carbohydrate catabolic process
cellular respiration
ATP metabolic process
energy derivation by oxidation of organic compounds
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
mitochondrial matrix
generation of precursor metabolites and energy
nucleotide metabolic process
nucleoside phosphate metabolic process
carbohydrate metabolic process
monocarboxylic acid metabolic process
nucleobase-containing small molecule metabolic process
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
organophosphate metabolic process
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process